| Product Name | P/Q-Calcium Channel Antibody (LEMS® Assay) - RIA |
| Catalog-No. | RA117/25 |
| Description | Radio Receptor Assay for the quantitative determination of autoantibodies against the voltage-gated calcium-channel (VGCC) in serum or plasma. Purified calcium channels of P/Q-subtype, labelled with 125I-ω-Conotoxin MVIIC |
| Format | 25 Determinations, 1 positive and 1 negative control |
| Procedure | 2 x 25 µl diluted (1:10) patient serum or plasma
1. incubation: 1 hour at room temperature
2. incubation: 1 hour at room temperature |
| Clinical Fields | Neurology, Immunology, Autoimmune Diseases |
| Diseases | Lambert-Eaton Syndrome; differential diagnosis of myasthenic syndromes |
| Normal Value | Healthy donors <30 pmol/l (n=160); reference range up to 40 pmol/l |
| Specificity | Samples of the following patient groups were measured: SLE, Diabetes mellitus (IDDM), Graves' Disease, Hashimoto Thyreoiditis, Myasthenia gravis, Addisons' Disease and RA. None of these samples showed positive values (100%). |
| Sensitivity | 50 patients with known Lambert-Eaton Syndrome - with and without small cell lung carcinoma - were measured. All samples showed concentrations above 40 pmol/l (100%). |
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